Accelerated Evolution of H7N9 Subtype Influenza Virus under Vaccination Pressure

Isolation and Identification of Avian Influenza Virus H9N2 Subtype

Evolution and Vaccination of Influenza Virus

In this study, we present an application paradigm in which an unsupervised machine learning approach is applied to the high-dimensional influenza genetic sequences to investigate whether vaccine is a driving force to the evolution of influenza virus. We first used a visualization approach to visualize the evolutionary paths of vaccine-controlled and non-vaccine-controlled influenza viruses in a...

Hierarchical hydropathic evolution of influenza glycoproteins (N2, H3, A/H3N2) under relentless vaccination pressure

Hemagglutinin (HA) and neuraminidase (NA) are highly variable envelope glycoproteins. Here hydropathic analysis, previously applied to quantify common flu (H1N1) evolution (1934-), is applied to the evolution of less common but more virulent (avian derived) H3N2 (1968-), beginning with N2. Whereas N1 exhibited opposing migration and vaccination pressures, the dominant N2 trend is due to vaccina...

An analysis of microbiota-targeted therapies in patients with avian influenza virus subtype H7N9 infection

BACKGROUND Selective prophylactic decontamination of the digestive tract is a strategy for the prevention of secondary nosocomial infection in patients with avian influenza virus subtype H7N9 infection. Our aim was to summarize the effectiveness of these therapies in re-establishing a stable and diverse microbial community, and reducing secondary infections. METHODS Comprehensive therapies we...

Punctuated evolution of influenza virus hemagglutinin (A/H1N1) under opposing migration and vaccination pressures

Influenza virus contains two highly variable envelope glycoproteins, hemagglutinin (HA) and neuraminidase (NA). The structure and properties of HA, which is responsible for binding the virus to the cell that is being infected, change significantly when the virus is transmitted from avian or swine species to humans. Previously we identified much smaller human individual evolutionary amino acid m...